PUBLICATIONS
REVIEWS
Systemic therapies in hepatocellular carcinoma: A revolution? Fortuny M, Sanduzzi-Zamparelli M, Reig M. S
United European Gastroenterol J. 2024; 10.1002/ueg2.12510 ;
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Navigating the landscape of liver cancer management: Study designs in clinical trials and clinical practice.  Cabibbo, G., Celsa, C., Rimassa, L., Torres, F., Rimola, J., Kloeckner, R., Bruix, J., Cammà, C., & Reig, M. (2024).
Journal of hepatology 2024 10.1016/j.jhep.2024.01.018 ;
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BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update
Maria Reig 1, Alejandro Forner 2, Jordi Rimola 3, Joana Ferrer-Fàbrega 4, Marta Burrel 5, Ángeles Garcia-Criado 3, Robin K Kelley 6, Peter R Galle 7, Vincenzo Mazzaferro 8, Riad Salem 9, Bruno Sangro 10, Amit G Singal 11, Arndt Vogel 12, Josep Fuster 13, Carmen Ayuso 14, Jordi Bruix 15
J Hepatol 2022;76(3):681-693
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Clinical presentation, diagnosis and staging of cholangiocarcinoma
Forner A, Vidili G, Rengo M, Bujanda L, Ponz-Sarvisé M, Lamarca A

Liver International 2019;10.1111/liv.14086
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Carbon-ion radiotherapy for HCC-A potential tool to fulfil an unmet gap in the treatment algorithms?
Da Fonseca LG, Forner A. Liv Int 2018;38:2132-2133
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Should Patients With NAFLD/NASH Be Surveyed for HCC?
Reig M, Gambato M, Man NK, Roberts JP, Victor D, Orci LA, Toso C. Transplantation 2019;103:39-44
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New Systemic Treatments in Advanced Hepatocellular Carcinoma
 
Sanduzzi-Zamparelli M, Díaz-Gonzalez Á, Reig M

Liver Transplantation 2018;doi: 10.1002/lt.25354
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Systemic therapy for intermediate and advanced hepatocellular carcinoma: Sorafenib and beyond
Raoul JL, Kudo M, Finn RS, Edeline J, Reig M, Galle PR

Cancer Treat Rev. 2018;68:16-24
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Evaluating the response to locoregional and systemic treatment for hepatocellular carcinoma
 
Darnell A, Belmonte E, Reig M, Brú C

Radiologia 2018;60:424-436
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New trials and results in systemic treatment of HCC
Reig M, da Fonseca LG, Faivre S

J Hepatology 2018;69:525-533
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EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma

Galle PR, Forner A, Llovet JM, Mazzaferro V, Piscaglia F, Raoul JL, Schirmacher P, Vilgrain V J Hepatology 2018;:doi: 10.1016/j.jhep.2018.03.019
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Lenvatinib: can a non-inferiority trial change clinical practice?
Reig M, Bruix J

Lancet 2018;391:1123-1124
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Hepatocellular Carcinoma

Alejandro Forner, María Reig, Jordi Bruix

The Lancet 2018;10127:1301-1314
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Updated use of TACE for hepatocellular carcinoma treatment: How and when to use it based on clinical evidence
Raoul JL, Forner A, Bolondi L, Cheung TT, Kloeckner R, de Baere T

Cancer Treat Rev. ;10.1016/j.ctrv.2018.11.002
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The success of regorafenib in hepatocellular carcinoma in a world of failures. Learnings for future developments

Reig M, Díaz-González Á, Bruix J Oncotarget 2017;8:106151-106152
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Liver Cancer Emergence Associated with Antiviral Treatment: An Immune Surveillance Failure?

 
Reig M, Boix L, Mariño Z, Torres F, Forns X, Bruix J. Seminars in Liver Disease 2017;
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Tumor biopsy and patient enrollment in clinical trials for advanced hepatocellular carcinoma

Rimassa L, Reig M, Abbadessa G, Peck-Radosavljevic M, Harris W, Zagonel V, Pastorelli D, Rota Caremoli E, Porta C, Damjanov N, Patel H, Daniele B, Lamar M, Schwartz B, Goldberg T, Santoro A, Bruix J World J Gastroenterol 2017;
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Liver transplantation for hepatocellular carcinoma: outcomes and novel surgical approaches Sapisochin G, Bruix J

Nature Reviews. Gastroenterology and Hepatology 2017;14:203-217
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Liver transplantation for hepatocellular carcinoma: outcomes and novel surgical approaches
Sapisochin G., Bruix J.

Nat Rev Gastroenterol Hepatol 2017;:doi: 10.1038/nrgastro.2016.193
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Diagnosis and treatment of hepatocellular carcinoma. Update consensus document from the AEEH, SEOM, SERAM, SERVEI and SETH

Alejandro Forner, María Reig, María Varela, Marta Burrel, Jaime Feliu, Javier Briceno, Javier Sastre, Luis Martí-Bonmati, Josep María Llovet, José Ignacio Bilbao, Bruno Sangro, Fernando Pardo, Carmen Ayuso, Concepció Bru, Josep Tabernero y Jordi Bruix

 Medicina Clínica 2016;:doi: 10.1016/j.medcli.2016.01.028
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Evidence-based Diagnosis, Staging, and Treatment of Patients With Hepatocellular Carcinoma

Bruix J, Reig M, Sherman M. Gastroenterology 2016;:doi: 10.1053/j.gastro.2015.12.041
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Advances in targeted therapies for hepatocellular carcinoma in the genomic era. Llovet JM, Villanueva A, Lachenmayer A, Finn RS. Nat Rev Clin Oncol. 2015;Aug;:12(8):436. doi: 10.1038/nrclinonc.2015.121.
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New molecular therapies for hepatocellular carcinoma. Torrecilla S, Llovet JM. Clin Res Hepatol Gastroenterol. 2015;Jul 20.:pii: S2210-7401(15)00151-5. doi: 10.1016/j.clinre.2015.06.016.
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Systemic Treatment: Expecting Further Success. Gazzola A, Reig M, Di Donato R, Bruix J. Dig Dis. 2015;;Jul 6.:33(4):590-7. doi: 10.1159/000375349.
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Genetic Landscape and Biomarkers of Hepatocellular Carcinoma. Zucman-Rossi J, Villanueva A, Nault JC, Llovet JM. Gastroenterology. 2015;Jun 20.:pii: S0016-5085(15)00869-0. doi: 10.1053/j.gastro.2015.05.061.
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Hepatocellular carcinoma: Consensus, controversies and future directions. A report from the Canadian Association for the Study of the Liver Hepatocellular Carcinoma Meeting. Burak KW, Sherman M; Collaborators. Can J Gastroenterol Hepatol. 2015;May:29(4):178-84.
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Liver cancer: Approaching a personalized care. Bruix J, Han KH, Gores G, Llovet JM, Mazzaferro V. J Hepatol. 2015;Apr:62(1S):S144-S156.
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Authors' response to the letter: Liver resection for patients with hepatocellular carcinoma and macrovascular invasion, multiple tumours or portal hypertension by Zhong et al. Bruix J, Gores G, Mazzaferro V. Gut. 2015;Mar:64(3):522.
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Biopsy for liver cancer: How to balance research needs with evidence-based clinical practice. Sherman M, Bruix J. Hepatology. 2015;Feb:61(2):433-7.
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Systemic therapy for hepatocellular carcinoma: the issue of treatment stage migration and registration of progression using the BCLC-refined RECIST. Reig M, Darnell A, Forner A, Rimola J, Ayuso C, Bruix J. Semin Liver Dis. 2014;Nov:34(4):444-55.
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Molecular profiling of liver tumors: classification and clinical translation for decision making. Pinyol R, Nault JC, Quetglas IM, Zucman-Rossi J, Llovet JM. Semin Liver Dis. 2014;Nov:34(4):363-75.
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Integration of genomic information in the clinical management of HCC. Quetglas IM, Moeini A, Pinyol R, Llovet JM. Best Pract Res Clin Gastroenterol. 2014;Oct:28(5):831-42
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Systemic treatment. Reig M, Gazzola A, Di Donato R, Bruix J. Best Pract Res Clin Gastroenterol. 2014;Oct;:28(5):921-35.
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Toward a better liver graft allocation that accounts for candidates with and without hepatocellular carcinoma. Toso C, Mazzaferro V, Bruix J, Freeman R, Mentha G, Majno P. Am J Transplant. 2014;Oct;:14(10):2221-7.
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Treatment of intermediate-stage hepatocellular carcinoma. Forner A, Gilabert M, Bruix J, Raoul JL. Nat Rev Clin Oncol. 2014;Sep;:11(9):525-35.
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Usefulness of the molecular profile in the diagnosis, prognosis and treatment of hepatocellular carcinoma Bruix J. Gastroenterol Hepatol. 2014;Jul;:37 Suppl 2:81-9.
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LI-RADS (Liver Imaging Reporting and Data System): Summary, discussion, and consensus of the LI-RADS Management Working Group and future directions. Mitchell DG, Bruix J, Sherman M, Sirlin CB. Hepatology. 2014;Jul 12.
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Treatment of hepatocellular carcinoma. Liccioni A, Reig M, Bruix J. Dig Dis. 2014;:32(5):554-63.
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Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma. Bridgewater J, Galle PR, Khan SA, Llovet JM, Park JW, Patel T, Pawlik TM, Gores GJ. J Hepatol. 2014;Jun;:60(6):1268-89.
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Hepatocellular carcinoma: genome-scale metabolic models for hepatocellular carcinoma. Pinyol R, Llovet JM. Nat Rev Gastroenterol Hepatol. 2014;Jun;:11(6):336-7.
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Liver cancer in 2013: Mutational landscape of HCC--the end of the beginning. Villanueva A, Llovet JM. Nat Rev Clin Oncol. 2014 ;Feb;:11(2):73-4.
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Hepatocellular carcinoma: clinical frontiers and perspectives.

Bruix J, Gores GJ, Mazzaferro V.

Gut. 2014;Feb 14.
Pubmed abstract
Consensus report of the Fifth International Forum for Liver MRI.

Zech CJ, Bartolozzi C, Bioulac-Sage P, Chow PK, Forner A, Grazioli L, Huppertz A, Laumonier H, Min Lee J, Murakami T, Ricke J, Sirlin CB.

AJR Am J Roentgenol. 2013;Jul;:201(1):97-107.
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The size of the problem: clinical algorithms. Forner A, Bruix J Dig Dis. 2013;31(1):95-103.
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Rethinking future development of molecular therapies in hepatocellular carcinoma: a bottom-up approach. Villanueva A. Journal of Hepatology 2013;Mar 30
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Medical therapies for hepatocellular carcinoma: a critical view of the evidence. Villanueva A, Hernandez-Gea V, Llovet JM. Nat Rev Gastroenterol Hepatol 2013;Jan
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New OPTN/UNOS policy for liver transplant allocation: standardization of liver imaging, diagnosis, classification, and reporting of hepatocellular carcinoma. Wald C, Russo MW, Heimbach JK, Hussain HK, Pomfret EA, Bruix J. Radiology 2013;266:376-382
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EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. Eur J. Cancer. 2012;48:599-641.
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EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. J. Hepatol. 2012;56:908-943.

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Saudi guidelines for the diagnosis and management of hepatocellular carcinoma: technical review and practice guidelines. Abdo AA, Hassanain M, Aljumah A, Al Olayan A, Sanai FM, Alsuhaibani HA, Abdulkareem H, Abdallah K, Almuaikeel M, Al Saghier M, Babatin M, Kabbani M, Bazarbashi S, Metrakos P, Bruix J. Ann Saudi Med 2012;32:174-199.
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Hepatocellular Carcinoma. Forner A, Llovet JM, Bruix J. Lancet 2012;379:1245-1255.
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Management of hepatocellular carcinoma. Rodriguez de Lope C, Tremosini S, Forner A, Reig M, Bruix J. J Hepatol. 2012;56 :75-87
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Gene signatures in the management of hepatocellular carcinoma. Hoshida Y, Moeini A, Alsinet C, Kojima K, Villanueva A. Semin Oncol. 2012;Aug
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Clinical decision making and research in hepatocellular carcinoma: pivotal role of Imaging techniques. J Brix, M Reig, J Rimola, A Forner, M Burrel, R Vilana, C Ayuso. Hepatology 2011;54:2238-2244.
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Management of hepatocellular carcinoma: an update. J Bruix, M Sherman. Hepatology 2011;53:1020-1022.
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The state of hepatitis B and C in Europe: report from the hepatitis B and C summit conference. A Hatzakis, S. Wait, J Bruix, M. Buti, M. Carballo, M. Cavaleri, M. Colombo, E Delarocque-Astagneau, G Dusheiko, G Esmat, R Esteban, D Goldberg, C Gore, AS Lok, M Manns, P Marcellin, G Papatheodoridis, A Peterle, D Prati, N Piorkowsky, M Rizzetto, F Roudot-Thoraval, V Soriano, HC Thomas, M Thursz, D Valla, P van Damme, IK Veldhuijzen, H Wedemeyer, L Wiessing, AR Zanetti, HL Janssen. J. Viral Hepat. 2011;18 :1-16
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What is the best staging system for hepatocellular carcinoma in the setting of liver transplantation? Olthoff KM, Forner A, Hübscher S, Fung J. Liver Transpl. 2011;Oct
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Targeted therapies for hepatocellular carcinoma. Villanueva A, Llovet JM. Gastroenterology 2011;May
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Evolving strategies for the management of intermediate-stage hepatocellular carcinoma: available evidence and expert opinion on the use of transarterial chemoembolization. Raoul JL, Sangro B, Forner A, Mazzaferro V, Piscaglia F, Bolondi L, Lencioni R. Cancer Treat Rev. 2011;May
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Signaling pathways in hepatocellular carcinoma. Sia D, Villanueva A. Oncology 2011;81
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Molecular pathogenesis of hepatocellular carcinoma Cornellà H, Alsinet C, Villanueva A. Alcohol Clin Exp Res. 2011;May
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